The Museum was built during the lifetime of the artist, next to his home and studio. Since 1967, it has operated as a branch of the National Art Gallery in Yerervan.
The spacious halls of the three-storey building exhibit those hangings which the artist never parted with in his lifetime.

The collection of the museum comprises 160 canvases which the artist executed in different periods of his life. Many of them have earned him world renown. Mainly his early works are placed on view here: «Tales and Dreams» (1904—1907), «At the Well. A Hot Day» (1908), «Self-Portrait» (1909), «Istanbul Dogs» (1910), apart from dozens of canvases painted in the Soviet period: «Aragats» (1925), «A Yard in Yerevan» (1929), «Three Ages» (1943), «Picking Cotton in the Valley of Ararat» (1949) and others symbolizing the revival of the Armenian people.

Martiros Sarian's pieces of art have combined into one the traditions of the past and the present. He consecrated all his life to his socialist fatherland, to the happy Armenian people building a bright future.